Alka-Seltzer Plus 4 Count Cold Formula. Expiration date: April, 2010. Ready to go to work the instant you take it. Alka-Seltzer Plus Cold Medicine is alive with effervescence - It rushes medicine to break up your worst cold symptoms fast. Alka-Seltzer Plus Original Effervescent contains a fever reducer, to bring down your fever and help you feel better fast. Alka-Seltzer Plus Original Effervescent Cold Relief Tablets: temporarily relieves these symptoms due to a cold or flu with cough: Minor aches and pains, Nasal and sinus Congestion. Coughing, Headache, Sore Throat, sneezing, runny nose, Temporarily reduces fever. 4 tablets per box.